NOMID: The radiographic and MRI features and review of literature

Authors

  • Faizah Mohd Zaki
  • Radhika Sridharan
  • Tan Sook Pei
  • Tang Swee Ping
  • Sharaf Ibrahim

DOI:

https://doi.org/10.3941/jrcr.v6i3.745

Keywords:

NOMID, CINCA, Neonate, Radiograph, MRI

Abstract

Neonatal onset multisystem inflammatory disease (NOMID) is a rare autoinflammatory disorder, which manifests early in infancy. We describe a case of a 10-year-old boy who has been unwell since infancy. He presented with urticarial rash, intermittent fever and hepatosplenomegaly followed by progressive arthropathy. His joint symptoms started at two years of age, which progressively involved multiple joints, resulting in bone and joint deformities. A series of joint radiographs demonstrated bizarre enlarging physeal mass with heterogenous calcification. Magnetic resonance imaging (MRI) of the involved right ankle and knee showed characteristic thickened and calcified physeal lesions, which enhanced post-gadolinium. This debilitating disease is also known to involve the central nervous system and eyes. This case report aims to highlight the conventional radiographic and magnetic resonance imaging (MRI) findings of this physeal abnormality in NOMID syndrome.

Author Biographies

Faizah Mohd Zaki

Radiologist,

Department of Radiology.

UKM Medical Center

Radhika Sridharan

Radiologist,

Department of Radiology.

UKM Medical Center.

Tan Sook Pei

Radiologist,

Department of Radiology.

UKM Medical Center

Tang Swee Ping

Department of Pediatrics, 

Selayang Hospital

Sharaf Ibrahim

Department of Orthopaedics,

UKM Medical Center

Journal of Radiology Case Reports March 2012 issue - Breast Fibromatosis Response to Tamoxifen: Dynamic MRI Findings and Review of the Current Treatment Options by Plaza et al.

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Published

2012-03-11

Issue

Vol. 6 No. 3 (2012)

Section

Musculoskeletal Radiology

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