Non-Small Cell Lung Carcinoma in Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Case Report and Imaging Findings

Authors

Krishna Doshi Department of General Medicine, Gladstone Hospital, Australia

DOI:

Abstract

Background: Syndrome of inappropriate antidiuretic hormone secretion occurs due to unsuppressed anti-diuretic hormone secretion, leading to hyponatraemia and hypovolaemia or euvolemia. Etiologies range from drugs, central nervous system insults to malignancy. NSCLC accounts for 80-85% of lung cancers, however is only found in 2-4% of cases with SIADH.

Case summary: A 63 year old female presented with two week history of worsening constipation, urinary retention and lower back pain. Laboratory testing identified hyponatraemia, hyposmolality and CXR and CT chest revealed left lower zone mass. Biopsy confirmed NSCLC.

Conclusion: SIADH has a broad aetiology and may be due to rare pathologies such as NSCLC. A high index of suspicion should remain, as not all cases may present with respiratory symptoms and rare but critical diagnoses should not be missed.

63 year old female with microscopic histopathology (20x magnification) showing non-small cell lung carcinoma

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Published

2024-10-30

Issue

Vol. 18 No. 10 (2024)

Section

Thoracic Radiology

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