Parathyroid Carcinoma, an Uncommon Diagnosis

Authors

  • Mina Al-Ani SUNY Downstate Health Science University, Radiology Department, Brooklyn, USA
  • Sean Mooney SUNY Downstate Health Science University, Otolaryngology Department, Brooklyn, USA
  • Zeliha Celen-Simsek SUNY Downstate Health Science University, Pathology Department, Brooklyn, USA
  • Mossum Sawhney SUNY Downstate Health Science University, Radiology Department, Brooklyn, USA
  • Deborah L. Reede SUNY Downstate Health Science University, Radiology Department, Brooklyn, USA

DOI:

https://doi.org/10.3941/jrcr.5339

Abstract

Parathyroid carcinoma should be considered in patients with clinical manifestations of severe hyperparathyroidism and hypercalcemia and corresponding abnormal laboratory values. Findings on several imaging modalities are highly suggestive of the diagnosis and often reveal malignant features, including local invasion or disseminated disease. Ultrasonography further aids in localizing the lesion and preoperative planning. 99mTc-sestamibi scintigraphy is also valuable in lesion localization, especially with delayed-phase image acquisition, although false negative results can occur. Surgical resection, along with prospective histopathological examination, is the primary treatment. The role of chemotherapy and radiation therapy remains controversial. Here, we present a case of a 67-year-old woman with histopathology-confirmed parathyroid carcinoma despite a negative 99mTc-sestamibi scintigraphy.

Coronal Planar SPECT, images of a 99mTc-sestamibi (MIBI) scan, demonstrate physiologic symmetric thyroid glandular radiopharmaceutical uptake and wash-out without abnormal parathyroid activity

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Published

2024-10-30

Issue

Vol. 18 No. 10 (2024)

Section

Neuroradiology

License

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