Biopsy Proven Cerebral Amyloid Related Inflammation Causing Vasogenic Edema with Midline Shift

Authors

Hannah Kelly Department of Neurology, Madigan Army Medical Center, Tacoma
Josh Spirnak Department of Radiology, Madigan Army Medical Center, Tacoma
Erik Dedekam Department of Radiology, Madigan Army Medical Center, Tacoma

DOI:

Abstract

Cerebral amyloid angiopathy related inflammation is a rare condition that can present with rapid cognitive impairment, seizures, and headaches. Imaging typically shows the underling microbleeds and signs of inflammation; however, a brain biopsy is needed for a definitive diagnosis. Once diagnosed, treatment tends to be immunosuppression. Here, we present a severe case confirmed with brain biopsy with classic imaging of this infrequently seen condition.

Author Biographies

Hannah Kelly, Department of Neurology, Madigan Army Medical Center, Tacoma

Department of Neurology; resident

Josh Spirnak, Department of Radiology, Madigan Army Medical Center, Tacoma

Axial post-contrast T2 FLAIR images (A and B) showing extensive vasogenic edema with cortical involvement affecting the right temporal, parietal and occipital lobes, causing 8 mm of leftward midline shift. Axial GRE (C) shows scattered cortical/subcortical microhemorrhages. Axial post-contrast T2 FLAIR (D) shows marked improvement in edema with mild residual edema in the right occipital lobe following treatment

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Published

2026-03-31

Issue

Vol. 20 No. 3 (2026)

Section

Neuroradiology

License

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