Pleomorphic Sarcoma in a Patient with Osteopetrosis

Authors

  • Kevin C McGill
  • Daria Motamedi
  • Nima Azimi
  • Andrew Horvai
  • Richard J O'Donnell

DOI:

https://doi.org/10.3941/jrcr.v14i7.3920

Keywords:

bone scintigraphy, humerus, malignant fibrous histiocytoma, osteopetrosis, undifferentiated pleomorphic sarcoma of bone

Abstract

Osteopetrosis comprises a rare, heterogeneous group of heritable conditions that are characterized by a defect in bone resorption by osteoclasts. We report the case of a 53-year-old woman with previously undiagnosed osteopetrosis who presented with a pathologic proximal humeral fracture secondary to pleomorphic sarcoma, which is previously undescribed in the English literature. Management of the primary lesion necessitated ablative surgery, but the malignancy nonetheless was associated with rapidly progressive metastatic disease.

Author Biographies

Kevin C McGill

Kevin McGill MD, MPH

Assistant Professor

Department of Radiology and Biomedical Imaging

University of California, San Francisco

400 Parnassus Ave.
San Francisco, CA 94143

Daria Motamedi

Daria Motamedi MD

Associate Professor

Department of Radiology and Biomedical Imaging

University of California, San Francisco

400 Parnassus Ave. 
San Francisco, CA 94143

Nima Azimi

Nima Azimi MD 

Resident

Department of Radiology

Massachusetts General Hospital

55 Fruit St.

Boston, MA 02114

Andrew Horvai

Andrew Horvai MD PhD

Clinical Professor

Department of Pathology

University of California, San Francisco

UCSF Medical Center Mission Bay 
1825 Fourth Street, Room M2354
San Francisco, CA 94143

Richard J O'Donnell

Richard J O'Donnell, MD 
Professor of Clinical Orthopaedic Surgery 

University of California, San Francisco

UCSF Bakar Precision Cancer Medical Building
1825 Fourth Street, 6th Floor
San Francisco, CA 94143

Penetrating chest trauma after attempted suicide: An extraordinary behavior of a posttraumatic pulmonary artery pseudoaneurysm by Sylvia Nyilas et. al.

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Published

2020-07-14

Issue

Vol. 14 No. 7 (2020)

Section

Musculoskeletal Radiology

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