Diffusion, Perfusion, and Histopathologic Characteristics of Desmoplastic Infantile Ganglioglioma

Authors

  • Chang Yueh Ho
  • Melissa Gener
  • Jose Bonnin
  • Stephen Francis Kralik

DOI:

https://doi.org/10.3941/jrcr.v10i7.2715

Keywords:

pediatric brain tumors, desmoplastic infantile ganglioglioma, MRI, perfusion, diffusion

Abstract

We present a case series of a rare tumor, the desmoplastic infantile ganglioglioma (DIG) with MRI diffusion and perfusion imaging quantification as well as histopathologic characterization.  Four cases with pathologically-proven DIG had diffusion weighted imaging (DWI) and two of the four had dynamic susceptibility contrast imaging.    All four tumors demonstrate DWI findings compatible with low-grade pediatric tumors.  For the two cases with perfusion imaging, a higher relative cerebral blood volume was associated with higher proliferation index on histopathology for one of the cases.  Our results are discussed in conjunction with a literature review.

Author Biographies

Chang Yueh Ho

Assistant Professor, Radiology: Indiana University School of Medicine

Fellowship Director Pediatric Neuroradiology

Clinical Director: Pediatric Neuroradiology, Riley Children's Hospital

Melissa Gener

Neuropathology Fellow

Department of Pathology, Indiana University School of Medicine

Jose Bonnin

Clinical Professor

Director, Neuropathology Fellowship Program 

Stephen Francis Kralik

Assistant professor of Radiology, Indiana University School of Medicine
Journal of Radiology Case Reports July 2016 issue - Cover page: Diffusion, Perfusion, and Histopathologic Characteristics of Desmoplastic Infantile Ganglioglioma by Chang Y Ho et al.

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Published

2016-07-10

Issue

Vol. 10 No. 7 (2016)

Section

Neuroradiology

License

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