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Click 50 year old male with retroperitoneal and mediastinal adenopathy. Initial axial Chest CT scan with contrast at the level of the splenic vein showing right retrocrural, celiac and mesenteric adenopathy with a ``misty`` appearance of mesenteric fat. This was the inferior most slice on the scan.

Click 50 year old male with retroperitoneal and mediastinal adenopathy. Axial fused PET/CT at the level of the testicles after intravenous administration of 14.4 mCi of FDG demonstrating asymmetric testicular activity with right testicular uptake with SUVmax of 9.6.

Click 50 year old male with known diffuse large B-cell non-Hodgkin's lymphoma. Axial fused PET/CT at the level of the testicles after intravenous administration of 14.2 mCi of FDG demonstrating partial response to therapy but still asymmetric right testicular activity with SUVmax of 5.3 on the right.

Click 50 year old male with retroperitoneal and mediastinal adenopathy. MIP images of a PET at the level of the testicles after intravenous administration of 14.4 mCi of FDG demonstrating asymmetric testicular activity with right testicular uptake with SUVmax of 9.6.

Click 51 year old male with known diffuse large B-cell non-Hodgkin's lymphoma. Axial fused PET/CT at the level of the testicles after intravenous administration of 14.2 mCi of FDG demonstrating continued response to therapy but with some small residual asymmetric uptake of FDG in the right testicle with SUVmax on the right of 4.4 and SUVmax on the left of 3.7.

Click 51 year old male with known diffuse large B-cell non-Hodgkin's lymphoma. Axial fused PET/CT at the level of the testicles after intravenous administration of 15.965 mCi of FDG demonstrating isolated relapse within the right testicle with SUVmax now of 12.4.

Click 51 year old male with known diffuse large B-cell non-Hodgkin's lymphoma. Sagittal ultrasound of the right testicle showing a hypoechoic mass with irregular lobular margins in the posterior aspect of the right testicle with marked hypervascularity on Doppler ultrasound.

Click 51 year old male with known diffuse large B-cell non-Hodgkin's lymphoma. Right testicular pathologic specimen. H&E 4x - low power view, lymphomatous involvement on right with large atypical lymphocytes infiltrating around and destroying seminiferous tubules. Back to back seminiferous tubules on left side of image showing area without lymphomatous involvement. 20x CD20 immunohistochemical stain for B-cells showing positivity of the lymphoma cells for CD20.