The Teaching Point

Particle disease, an asymptomatic illness that will lead to aseptic loosening, can be differentiated from metastasis, infection, or non-infectious etiology by 3-phase bone scan and 18F-Fluoride PET/CT. On F-18 PET/CT, particle disease shows up as a well-defined, intense uptake surrounding an erosive lesion of bone with the lesion tracking along the screw. As the prevalence increases, proper recognition by CT, bone scintigraphy, or PET will dictate management of prosthetics.






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From the manuscript

Particle Disease on Fluoride-18 (NaF) PET/CT imaging

Free full text article: Particle Disease on Fluoride-18 (NaF) PET/CT imaging

Abstract
Particle disease is a loss of bone that commonly occurs about five years after arthroplasty. The cause is secondary to microabrasive wear and shedding of any portion of the prosthesis, and the microscopic foreign bodies activate inflammation which can lead to pain. This report describes the imaging findings of an 80-year-old female with particle disease detected with 18F-fluoride PET/CT.






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