The Teaching Point

It is important to consider metastatic RCC in the setting of a new thyroid lesion resembling primary thyroid malignancy on imaging even years after nephrectomy. Since specific immunohistochemical staining is required to diagnose RCC metastases, consideration and proper communication with other health care professionals are required to mitigate the risk of a delayed diagnosis.






Bookmark and Share

From the manuscript

A Multimodal and Pathological Analysis of a Renal Cell Carcinoma Metastasis to the Thyroid Gland 11 Years Post Nephrectomy

Free full text article: A Multimodal and Pathological Analysis of a Renal Cell Carcinoma Metastasis to the Thyroid Gland  11 Years Post Nephrectomy

Abstract
Thyroid lesions have a comprehensive differential diagnosis which include benign and malignant entities, such as metastases. However, metastases only account for a small percentage of thyroid lesions with renal cell carcinoma as the most common. Metastases to the thyroid pose a diagnostic dilemma as symptoms may not manifest for up to decades after removal of the renal cell carcinoma. Due to the nonspecific appearance on computed tomography and ultrasound, distinguishing metastases from primary thyroid malignancies is of the utmost importance for timely patient management. Our case demonstrates the importance of considering RCC metastases to the thyroid even years after nephrectomy to mitigate potential delays in diagnosis. We present the case of a 66-year-old male with a past medical history of renal cell carcinoma status post nephrectomy 11 years prior who demonstrated incidental thyroid abnormalities on positron emission tomography/computed tomography and ultrasound later confirmed as a metastasis of renal cell carcinoma.






References



1. Hegerova L, Griebeler ML, Reynolds JP, Henry MR, Gharib H. Metastasis to the Thyroid Gland. Am J
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


2. Chung AY, Tran TB, Brumund KT, Weisman RA, Bouvet M. Metastases to the Thyroid: A Review of the Literature from the Last Decade. Thyroid 2012 Nov;22(3):258-68
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


3. Yadav S, Bennani-Baiti N. Renal cell carcinoma metastasis to the thyroid: How long is long enough? Acta Oncol. 2014;53(9):1277-8
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


4. Heffess CS, Wenig BM, Thompson LD. Metastatic renal cell carcinoma to the thyroid gland: A clinicopathologic study of 36 cases. Cancer 2002 May;95(9):1869-78
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


5. Sindoni A, Rizzo M, Tuccari G. Thyroid metastases from renal cell carcinoma: Review of the literature. Scientific World Journal 2010 Apr;10:590-602
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


6. Koul H, Huh JS, Rove KO. Molecular aspects of renal cell carcinoma: a review. Am J
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


7. Zamarrón C, Abdulkader I, Areses MC, García-Paz V, León L, Cameselle-Teijeiro J. Metastases of Renal Cell Carcinoma to the Thyroid Gland with Synchronous Benign and Malignant Follicular Cell-Derived Neoplasms. Case Rep Oncol
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


8. Medas F, Calò PG, Lai ML, Tuveri M, Pisano G, Nicolosi A. Renal cell carcinoma metastasis to thyroid tumor: A case report and review of the literature. J Med
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


9. Macedo-Alves D, Koch P, Soares V, Gouveia P, Honavar M, Taveira-Gomes A. Thyroid metastasis from renal cell carcinoma - A case report after 9 years. Int J
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


10. Sountoulides P, Metaxa L, Cindolo L. Atypical presentations and rare metastatic sites of renal cell carcinoma: A review of case reports. J Med
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


11. Cilengir AH, Kalayci TO, Duygulu G, Atasever RT, İnci MF. Metastasis of Renal Clear Cell Carcinoma to Thyroid Gland Mimicking Adenomatous Goiter. Polish J Radiol
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


12. Testini M, Lissidini G, Gurrado A, Lastilla G, Ianora AS, Fiorella R. Acute airway failure secondary to thyroid metastasis from renal carcinoma. World J Surg
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


13. Riaz K, Tunio MA, Alasiri M, Elbagir Mohammad AA, Fareed MM. Renal cell carcinoma metastatic to thyroid gland, presenting like anaplastic carcinoma of thyroid. Case Rep Urol
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


14. Razzaq F, Alam N, Lane L. Renal carcinoma metastasis in thyroid gland mimicking a benign goiter. Eurorad, Case 14612, 2017 Available at: http://www.eurorad.org/case.php?id=14612 Accessed August 10, 2018.
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


15. Kobayashi K, Hirokawa M, Yabuta T. Metastatic carcinoma to the thyroid gland from renal cell carcinoma: Role of ultrasonography in preoperative diagnosis. Thyroid Res 2015;8(1)
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


16. Song OK, Koo JS, Kwak JY, Moon HJ, Yoon JH. Metastatic renal cell carcinoma in the thyroid gland: ultrasonographic features and the diagnostic role of core needle biopsy. Ultrasonography 2016 Nov;36(3):1-8
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


17. Adamczewski Z, Dedecjus M, Skowrońska-Jóźwiak E, Lewiński A. Metastases of renal clear-cell carcinoma to the thyroid: a comparison of shear?wave and quasi?static elastography. Polskie Archiwum Medycyny Wewnetrznej 2014;124(9):485-86
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


18. Andrioli M, Persani L. Elastographic presentation of synchronous renal cell carcinoma metastasis to the thyroid gland. Endocrine Imaging 2013;2(1):37-48
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


19. Lee JG, Yang Y, Kim K. A case of metastatic renal cell carcinoma to thyroid gland. Chonnam Med J
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


20. Kim Y, Lee JJ, Paik JH, Kim YK, Kim SE. Detection of Thyroid Metastasis of Renal Transitional Cell Carcinoma Using FDG PET/CT. Nucl Med
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


21. Ma H, Shen G, Liu B, Yang Y, Ren P, Kuang A. Diagnostic performance of 18F-FDG PET or PET/CT in restaging renal cell carcinoma: a systematic review and meta-analysis. Nuclear Medicine Communications 2017;38(2):156-63
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


22. Lang BHH, Law TT. The Role of 18F-Fluorodeoxyglucose Positron Emission Tomography in Thyroid Neoplasms. The Oncologist 2011;16:458-66
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


23. Manohar K, Mittal BR, Kashyap R, Bhattacharya A, Singh B. Renal cell carcinoma presenting as isolated thyroid metastasis 13 years after radical nephrectomy, detected on F-18 FDG PET/CT. Clin Nucl
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


24. Foppiani L, Massollo M, Del Monte P, Bandelloni R, Arlandini A, Piccardo A. Late-onset metastasis of renal cell carcinoma into a hot thyroid nodule: an uncommon finding not to be overlooked. Case Rep Endocrinol
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


25. Razek AAK, Sadek AG, Kombar OR, Elmahdy TE, Nada N. Role of Apparent Diffusion Coefficient Values in Differentiation Between Malignant and Benign Solitary Thyroid Nodules. AJNR Am J Neuroradiol 2008;29(3):563-68
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


26. Chin CJ, Franklin JH, Moussa M, Chin JL. Metastasis from renal cell carcinoma to the thyroid 12 years after nephrectomy. CMAJ 2011 Sep;183(12):1398-9
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


27. Iesalnieks I, Machens A, Bures C. Local Recurrence in the Neck and Survival After Thyroidectomy for Metastatic Renal Cell Carcinoma. Ann Surg
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


28. Takashima S, Sone S, Takayama F, et-al. Papillary thyroid carcinoma: MR diagnosis of lymph node metastasis. AJNR Am J Neuroradiol 1998 Mar;19(3):509-13
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


29. Bin Saeedan M, Aljohani IM, Khusaim AO, Bukhari SQ, Elnaas ST. Thyroid computed tomography imaging: pictorial review of variable pathology. Insights Imaging 2016 May;7(4):601-7
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


30. Nachiappan AC, Metwalli ZA, Hailey BS, Patel RA, Ostrowski ML, Wynne DM. The Thyroid: Review of Imaging Features and Biopsy Techniques with Radiologic-Pathologic Correlation. RadioGraphics 2014;34(2):276-293
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


31. Wunderbaldinger P, Harisinghani MG, Hahn PF, et-al. Cystic lymph node metastases in papillary thyroid carcinoma. AJR Am J Roentgenol 2002;178(3):693-7
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


32. Hoang JK, Lee WK, Lee M, Johnson D, Farrell S. US Features of Thyroid Malignancy: Pearls and Pitfalls. RadioGraphics 2007;27(3):847-860
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


33. Lee SH, Han S, Lee HS. Association Between 18F-FDG Avidity and the BRAF Mutation in Papillary Thyroid Carcinoma. Nucl Med Mol Imaging 2016;50(1):38-45
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


34. Araz M, Çayır D. 18F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography for Other Thyroid Cancers: Medullary, Anaplastic, Lymphoma and So Forth. Molecular Imaging Radionucl Ther 2017;26(1):1-8
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


35. Lee JW, Yoon DY, Choi CS. Anaplastic thyroid carcinoma: Computed tomographic differentiation from other thyroid masses. Acta radiol 2008;49(3):321-27
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine




Search for articles with similar topics:

Keyword search:

1. Neoplasm Metastasis

2. Thyroid Gland

3. Hypervascular Mass

4. Carcinoma, Renal Cell

5. Ultrasonography

6. Positron Emission Tomography Computed Tomography

7. Computed Tomography


This article belongs to the General section.


Search for more in the Internet

Peer-reviewed Radiology Search




Discuss it!

Bookmark and Share




© Journal of Radiology Case Reports - The Interactive Radiology Journal
Affiliated journal of Radiolopolis - The International Radiology Community


The Journal of Radiology Case Reports