Learning Tables







Learning Tables






Bookmark and Share

From the manuscript

Extramedullary multiple myeloma with central nervous system and multiorgan involvement: Case report and literature review

Free full text article: Extramedullary multiple myeloma with central nervous system and multiorgan involvement:  Case report and literature review

Abstract
Multiple myeloma is a hematologic malignancy due to monoclonal plasma cell proliferation. It is usually confined to the bone marrow, although extramedullary involvement is known to occur in almost any organ system; myelomatous spread to the central nervous system is a rare manifestation of myeloma. Extramedullary disease is thought to be related to hematogenous spread when myeloma cells show decreased cell surface receptor expression, allowing cells to escape from the bone marrow. Disease outside of the bone marrow generally indicates a poor prognosis; central nervous system involvement is associated with a median prognosis of less than 6 months, thereby requiring more aggressive treatment paradigms. We herein describe an unusual case of a patient with extramedullary multiple myeloma with central nervous system and multiorgan involvement. Despite an aggressive treatment strategy, the patient died a few months later after the initial diagnosis. The etiology, diagnostic criteria, clinical presentation, radiological features and differential diagnosis of this patient with extramedullary multiple myeloma are discussed here. The current treatment strategies are also briefly discussed.






References



1. Cowan A, Allen C. Global Burden of Multiple Myeloma A Systematic Analysis for the Global Burden of Disease Study 2016. JAMA Oncol 2018;4(9):1221-1227
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


2. Ferraro R, Agarwal A, Martin-Macintosh EL, Pellar PJ, Subramaniam RM. MR Imaging and PET/CT in Diagnosis and Management of Multiple Myeloma. RadioGraphics 2015;35:438-454
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


3. Jurczyszyn A, Grzasko N. Central Nervous System Involvement by Multiple Myeloma: a Multi-Institutional Retrospective Study of 172 Patients in daily clinical practice. Am J Hematol 2016;91(6):575-80
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


4. Varettoni M, Corso A, Pica G, Mangiacavalli S, Pascutto C, Lazzarino M. Incidence, presenting features and outcome of extramedullary disease in multiple myeloma: a longitudinal study on 1003 consecutive patients. Ann Oncol 2010;21:325-330
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


5. Ames J, Al-Samaraee A, Takaha T. Extraosseous Multiple Myeloma: Case Report of Presentation in the Lower Extremity Soft Tissues with Literature Review. ," Case Reports in Radiology 2017;Article ID 9159035
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


6. Hall M, Jagannathan JP, Ramaiya NH, Shinagare AB, Van den Abbeele AD. Imaging of Extraosseous Myeloma: CT, PET/CT, and MRI Features. American Journal of Roentgenology 2010;195:1057-1065
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


7. Paludo J, Painuly U. Myelomatous Involvement of the Central Nervous System. Clin Lymphoma Myeloma Leuk 2016;16(11):644-654
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


8. Bladé J, Fernández de Larrea C, Rosiñol L, Cibeira MT, Jimenez R, Powles R. Soft-Tissue plasmacytomas in multiple myeloma: incidence, mechanisms of extramedullary spread, and treatment approach. J Clin Oncol 2011;29(28):3805-12
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


9. Touzeau C, Moreau P. How I treat extramedullary myeloma. Blood 2016;127(8):971-976
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


10. Rajkumar SV. Updated diagnostic criteria and staging system for multiple myeloma. Am Soc Clin Oncol Educ Book 2016;35:e418-e423
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


11. Wirk B, Wingard J, Moreb J. Extramedullary disease in plasma cell myeloma: the iceberg phenomenon. Bone Marrow Transplantation 2013;8(48):10-18
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


12. Hanrahan CJ, Christensen CR, Crim J. Current Concepts in the Evaluation of Multiple Myeloma with MR Imaging and FDG PET/CT. RadioGraphics 2010;30:127-142
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


13. Valla K, Kaufman JL. Bortezomib in Combination with Dexamethasone, Cyclophosphamide, Etoposide, and Cisplatin (V-DCEP) for the Treatment of Multiple Myeloma. Blood 2014;124:2139
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


14. Varga G, Mikala G. Multiple Myeloma of the Central Nervous System: 13 Cases and Review of the Literature. J Oncol 2018;23:3970169
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


15. Nayak L, Abrey LE, Iwamoto FM. Intracranial Dural Metastases. Cancer 2009 May 1;115(9): 1947-53
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


16. Iwamoto FM, Abrey LE. Primary dural lymphomas: a review. Neurosurg Focus 2006 Nov 15;21(5):E5
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


17. Lim M, Kheok SW, Lim KC, Venkatanarasimha N, Small JE, Chen RC. Subdural haematoma mimics. Clinical Radiology September 2019;74(9):663-675
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


18. Chiechi MV, Smirniotopoulos JG, Mena H. Intracranial Hemangiopericytomas: MR and CT Features. Am J Neuroradiol August 1996;17(7):1365-1371
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


19. Smith JK, Matheus MG, Castillo M. Imaging Manifestations of Neurosarcoidosis. AJR Am J Roentgenol 2004 Feb;182(2):289-95
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine




Search for articles with similar topics

Keyword search:

1. Central nervous system multiple myeloma

2. extraosseous multiple myeloma

3. extramedullary multiple myeloma

4. multiple myeloma

5. pachymeningeal disease


This article belongs to the General section.


Search for more in the Internet

Peer-reviewed Radiology Search




Discuss it!

Bookmark and Share




© Journal of Radiology Case Reports - The Interactive Radiology Journal
Affiliated journal of Radiolopolis - The International Radiology Community


The Journal of Radiology Case Reports