Question:

Which of the following regarding 18F-FDG PET for the diagnosis and grading of soft-tissue sarcoma is false?
1. 18F-FDG PET can differentiate between malignant and low-grade soft-tissue sarcomas.
2. 18F-FDG PET cannot differentiate between low-grade soft-tissue sarcomas and benign lesions.
3. 18F-FDG PET is a useful in the evaluation of both primary and recurrent soft-tissue lesions.
4. 18F-FDG PET is superior for assessing response to therapy for soft-tissue sarcomas.
5. 18F-FDG PET shows equivalent diagnostic performance as MRI for assessing local recurrence for soft-tissue sarcomas.





Answer:

The correct answer for the question "Which of the following regarding 18F-FDG PET for the diagnosis and grading of soft-tissue sarcoma is false?" is:

4. 18F-FDG PET is superior for assessing response to therapy for soft-tissue sarcomas.



Explanation
1. 18F-FDG PET can differentiate between malignant and benign soft-tissue sarcomas. [18F-FDG PET uptake was found in all high-grade and intermediate-grade soft-tissue sarcomas.]

2. 18F-FDG PET cannot differentiate between low-grade soft-tissue sarcomas and benign lesions. [Unfortunately, 18F-FDG PET cannot discriminate between low-grade tumors and benign lesions.]

3. 18F-FDG PET is a useful in the evaluation of both primary and recurrent soft-tissue lesions. [Diagnostic performance for primary and recurrent lesions was shown to be equivalent in recent studies.]

4. 18F-FDG PET is superior for assessing response to therapy for soft-tissue sarcomas. (applies) [Recent evidence suggests tyrosine PET may be superior to 18F-FDG PET when assessing response to therapy.]

5. 18F-FDG PET shows equivalent diagnostic performance as MRI for assessing local recurrence for soft-tissue sarcomas. [Recent evidence suggests an approximately equivalent diagnostic performance of the two modalities for assessing local recurrence.]



From the manuscript:
F-18 FDG PET/CT and Tc-99m Sulfur Colloid SPECT imaging in the diagnosis and treatment of a case of dual solitary fibrous tumors of the retroperitoneum and pancreas
Radiology Case. 2012 Mar; 6(3):32-37


This article belongs to the Nucs section.




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From the manuscript

F-18 FDG PET/CT and Tc-99m Sulfur Colloid SPECT imaging in the diagnosis and treatment of a case of dual solitary fibrous tumors of the retroperitoneum and pancreas

Free full text article: F-18 FDG PET/CT and Tc-99m Sulfur Colloid SPECT imaging in the diagnosis and treatment of a case of dual solitary fibrous tumors of the retroperitoneum and pancreas

Abstract
Although FDG PET is increasingly used for the staging of many types of sarcoma, little has been written regarding the FDG PET imaging characteristics of solitary fibrous tumor. We report a patient undergoing FDG PET/CT surveillance for squamous cell carcinoma of the tongue who was incidentally found to have two soft tissue masses in the retroperitoneum and pancreatic tail. Due to their low degree of FDG avidity, they were followed conservatively for approximately one year as they gradually increased in size. Technetium-99m sulfur colloid SPECT helped confirm that the pancreatic tail mass was not a splenule, after which both lesions were surgically resected and found to be extrathoracic solitary fibrous tumors without malignant features. These findings suggest that, as with other low-grade sarcomas, benign extrathoracic solitary fibrous tumors exhibit relatively little glycolytic metabolism in vivo.






References



1. Ali SZ, Hoon V, Hoda S, Heelan R, Zakowski MF. Solitary fibrous tumor. A cytologic-histologic study with clinical, radiologic, and immunohistochemical correlations Cancer (Cancer Cytopathol)
Get full text
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2. Thorgeirsson T, Isaksson HJ, Hardardottir H, Alfredsson H, Gudbjartsson T. Solitary fibrous tumors of the pleura: an estimation of population incidence. Chest 2010 Apr;137(4):1005-1006
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


3. de Perrot M, Fischer S, Bründler M, Sekine Y, Keshavjee S. Solitary fibrous tumors of the pleura. Ann Thorac Surg 2002 Jul;74(1):285-293
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


4. Takizawa I, Saito T. Primary solitary fibrous tumor (SFT) in the retroperitoneum. Urol Oncol 2008 May-Jun;26(3):254-259
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


5. Wakisaka N, Kondo S, Murono S, Minato H, Furukawa M, Yoshizaki T. A solitary fibrous tumor arising in the parapharyngeal space, with MRI and FDG-PET findings. Auris Nasus Larynx 2009 Jun;36(3):367-371
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


6. England DM, Hochholzer L, McCarthy MJ. Localized benign and malignant fibrous tumors of the pleura. A clinicopathologic review of 223 cases Am J Surg Pathol
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


7. Ioannidis J, Lau J. 18F-FDG PET for the diagnosis and grading of soft-tissue sarcoma: a meta-analysis. J Nucl Med 2003 May;44(5):717-724
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


8. Sugawara Y, Sakai S. Solitary fibrous tumor of the pancreas. Jpn J Radiol 2010 Jul;28(6):479- 482
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


9. Vossough A, Torigian DA, Zhang PJ, Siegelman ES, Banner MP. Extrathoracic solitary fibrous tumor of the pelvic peritoneum with central malignant degeneration on CT and MRI. J Magn Reson Imaging 2005 Nov:22(5):684-686
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


10. Crotty TB, Myers JL, Katzenstein AL, Tazelaar HD, Swensen SJ, Churg A. Localized malignant mesothelioma. A clinicopathologic and flow cytometric study Am J Surg Pathol
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


11. Hanau CA, Miettinen M. Solitary fibrous tumor: histological and immunohistochemical spectrum of benign and malignant variants presenting at different sites. Hum Pathol 1995 Apr;26(4):440-449
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


12. Robinson LA. Solitary fibrous tumor of the pleura. Cancer Control 2006 Oct;13(4):264-269
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


13. Park CK, Lee DH, Park JY, Park SH, Kwon KY. Multiple recurrent malignant solitary fibrous tumors: long-term follow-up of 24 years. Ann Thorac Surg 2011 Apr;91(4):1285-1288
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


14. Lucignani G, Paganelli G, Bombardieri E. The use of standardized uptake values for assessing FDG uptake with PET in oncology: a clinical perspective. Nucl Med Commun 2004 Jul;25(7):651-656
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


15. Schwarzbach MH, Dimitrakopoulou-Strauss A. Clinical value of [18-F]] fluorodeoxyglucose positron emission tomography imaging in soft tissue sarcomas. Ann Surg 2000 Mar;231(3):380-386
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


16. Kohler M, Clarenbach CF. Diagnosis, treatment and long-term outcome of solitary fibrous tumours of the pleura. Eur J Cardiothorac Surg 2007 Sep;32(3):403-408
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


17. Malaise EP, Chavaudra N, Tubiana M. The relationship between growth rate, labeling index and histological type of human solid tumors. Eur J Cancer 1973 Apr;9(4):305-312
Get full text
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1. Solitary Fibrous Tumor

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5. PET/CT

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7. SPECT


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