Question:

What imaging modality is the current "gold standard" for assessing lung morphology in patients with cystic fibrosis?
1. Magnetic resonance imaging.
2. Computerized tomography.
3. Ultrasound.
4. Plain film.
5. Positron Emission tomography Scan.





Answer:

The correct answer for the question "What imaging modality is the current "gold standard" for assessing lung morphology in patients with cystic fibrosis?" is:

2. Computerized tomography.



Explanation
Computerized tomography is the current "gold standard" for assessment of lung morphology in patients with cystic fibrosis. Magnetic resonance imaging is comparable to computerized tomography with regard to the detection of most morphological changes in the cystic fibrosis lung but it is less sensitive at detecting small airway disease. Endoscopic retrograde cholangiopancreatography may demonstrate multiple irregular filling defects throughout the biliary tree but is not the diagnostic "gold standard" [33]. Findings on plan film, Computerized tomography and Magnetic resonance imaging include linear atelectasis, dilated and thickened airways, and irregular peripheral opacities that may represent mucopurulent plugs. However, [Computerized tomography also shows airway dilatation, which can be detected as parallel lines or end-on ring shadows, bronchial wall thickening, mucopurulent plugs with post-obstructive air trapping, and cysts off the bronchial wall [32].]



From the manuscript:
Paucity of biliary ducts: A rare etiology of neonatal cholestasis
Radiology Case. 2012 Feb; 6(2):29-38


This article belongs to the Pediatric section.




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From the manuscript

Paucity of biliary ducts: A rare etiology of neonatal cholestasis

Free full text article: Paucity of biliary ducts: A rare etiology of neonatal cholestasis

Abstract
We report a case of a newborn with cholestasis that was diagnosed as nonsyndromic Alagille syndrome. The main feature of the disease is a paucity of biliary ducts. There are two known types of the disease: the syndromic type which is associated with other congenital defects and the nonsyndromic type without other anomalies detected at birth. We describe the case and discuss its clinical and radiologic findings. We also discuss the various etiologies of cholestasis that are included in the differential diagnosis.






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