Question:

What is the pattern of MRI bone signal in myelodysplastic syndrome?
1. Low signal in T1 weighted sequence and high signal in T2 weighted sequence
2. High signal in T1 weighted sequence and low signal in T2 weighted sequence
3. Low signal in T1 weighted sequence and low signal in T2 weighted sequence
4. High signal in T1 weighted sequence and high signal in T2 weighted sequence
5. None of the above





Answer:

The correct answer for the question "What is the pattern of MRI bone signal in myelodysplastic syndrome?" is:

1. Low signal in T1 weighted sequence and high signal in T2 weighted sequence



Explanation
In cases of leukemia and myelodysplastic syndrome there will be low signal in T1 weighted sequence and high signal in T2 weighted sequence.



From the manuscript:
Hyperostosis - an unusual radiographic presentation of Myelodysplastic Syndrome transformed to Acute Myeloid Leukemia
Radiology Case. 2010 Nov; 4(11):18-25


This article belongs to the Pediatric section.




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From the manuscript

Hyperostosis - an unusual radiographic presentation of Myelodysplastic Syndrome transformed to Acute Myeloid Leukemia

Free full text article: Hyperostosis - an unusual radiographic presentation of Myelodysplastic Syndrome transformed to Acute Myeloid Leukemia

Abstract
Acute myeloid leukemia (AML) is also referred to non-lymphocytic leukemia in the literature. It comprises about 15% of the childhood leukemia. There are multiple subtypes of AML from M0-M7 with approximately 45% of the cases being M0-M2 and the remaining subtypes being rare. The definitive diagnosis relies on bone marrow biopsy showing bone marrow infiltration with leukemic cells. We describe a rare radiographic presentation of myelodysplastic syndrome (MDS) transformed to AML in an 8 month old boy who presented with a orbital wall fracture, periosteal reaction, and mixed lytic and sclerotic lesions.






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