Question:

Which of the following answer choices is true?
1. Plasma cells derive from T lymphocytes.
2. Plasma cells derive from B lymphocytes.
3. Plasmablast is the mature form of plasma cells.
4. The role of each plasma cell is to produce different types of antibodies.
5. Plasma cells can proliferate only in the bone marrow.





Answer:

The correct answer for the question "Which of the following answer choices is true?" is:

2. Plasma cells derive from B lymphocytes.



Explanation
1- Plasma cells derive from T lymphocytes [In response to foreign antigens, B-cells will mature and transform into plasma cell].

2- Plasma cells derive from B lymphocytes [In response to foreign antigens, B-cells will mature and transform into plasma cells].

3- Plasmablast is the mature form of plasma cells [When the transformation of a stem cell to a B-cell is altered, it results in an abnormal or malignant plasma cell called plasmablast, a developmentally early form of plasma cell].

4- The role of each plasma cell is to produce different types of antibodies [The role of plasma cells is to produce millions of copies of the same antibody called immunoglobulin that recognizes the antigen].

5- Plasma cells can proliferate only in the bone marrow [These cells can proliferate in the bone marrow to form MM or, extramedullary in the soft tissue to form plasmacytoma].



From the manuscript:
Extramedullary duodenal plasmacytoma presenting with gastric outlet obstruction and painless jaundice
Radiology Case. 2010 Aug; 4(8):22-28


This article belongs to the GI section.




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From the manuscript

Extramedullary duodenal plasmacytoma presenting with gastric outlet obstruction and painless jaundice

Free full text article: Extramedullary duodenal plasmacytoma presenting with gastric outlet obstruction and painless jaundice

Abstract
Malignant plasma cells in multiple myeloma are predominantly confined to the medullary space of the skeletal system, therefore the disease course will be dominated by signs and symptoms related to bone marrow infiltration and destructive bone lesions with their consequences as well as abnormal protein production. Visceral extramedullary plasmacytoma involving the gastrointestinal system and particularly the duodenum is a rare manifestation of the disease. We report a case of duodenal extramedullary plasmacytoma presenting with gastric outlet obstruction and painless jaundice, in a patient treated for multiple myeloma. Diagnosis was first suggested on imaging, and proved by endoscopic biopsy. The duodenal mass resolved following chemotherapy.






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