Question:

The most common cause of lung cancer is:
1. Asbestos
2. Radon
3. Coal products
4. Halogen
5. Cigarette smoking





Answer:

The correct answer for the question "The most common cause of lung cancer is:" is:

5. Cigarette smoking



Explanation
Evidence from the literature confirms that asbestos, radon, coal products, halogen and cigarette smoking are all risk factors for lung cancer. However, cigarette smoking is well established to be the most common cause. [In general lung cancer is known to be caused by tobacco smoking in as many as 90% of patients, Table1].



From the manuscript:
Flare Response versus Disease Progression in Patients with Non-small Cell Lung Cancer
Radiology Case. 2012 Nov; 6(11):34-42


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From the manuscript

Flare Response versus Disease Progression in Patients with Non-small Cell Lung Cancer

Free full text article: Flare Response versus Disease Progression in Patients with Non-small Cell Lung Cancer

Abstract
We present a case report of a patient with metastatic non-small cell lung cancer (NSCLC) who had a series of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) scans for assessment of response to treatment. A restaging 18F-FDG PET/CT scan after six cycles showed increased FDG activity in the bone lesions with reduced activity in the lung and liver lesions. The increased bone activity was considered to be due to flare phenomenon rather than metastasis. A short interval follow up scan after 1 month was advised to confirm this interpretation but this repeat scan showed disease relapse. Although the flare phenomenon does exist, caution should be exercised in attributing increased tracer uptake in the lesions in patients with adenocarcinoma of lung and especially those who have received erlotinib during the course of their treatment. Distinguishing the `flare phenomenon` and `disease progression` is at times difficult but is important since misdiagnosis may result in an unnecessary delay in patient management.






References



1. Bordoni A, Bongioivanni M, Mazzucchelli L, Spitale A. Impact of histopathological diagnosis with ancillary immunohistochemical studies on lung cancer subtypes incidence and survival: a population-based studyJ Cancer Epidemiol. 2011;2011:275758 Epub 2011 Dec 29
Get full text
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2. Lind JS, Postmus PE, Smit EF. Osteoblastic bone lesions developing during treatment with erlotinib indicate major response in patients with non-small cell lung cancer: a brief report. J Thorac Oncol 2010 Apr;5(4):554-7
Get full text
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3. Wang M, Zhao J, Zhang LM, Li H, Yu JP, Ren XB, Wang CL. Combined Erlotinib and Cetuximab overcome the acquired resistance to epidermal growth factor receptors tyrosine kinase inhibitor in non-small-cell lung cancer. J Cancer Res Clin Oncol 2012 Jul 22
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


4. Chang MC, Chen JH, Liang JA, Lin CC, Yang KT, Cheng KY, Yeh JJ, Kao CH. Meta-analysis: comparison of F-18 fluorodeoxyglucose-positron emission tomography and bone scintigraphy in the detection of bone metastasis in patients with lung cancer. Acad Radiol 2012 Mar;19(3):349-57
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


5. Hoh CK, Schiepers C, Seltzer MA, Gambhir SS, Silverman DH, Czernin J, Maddahi J, Phelps ME. PET in oncology: will it replace the other modalities? Semin Nucl Med. 1997 Apr;27(2):94-106 Review
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


6. Song JW, Oh YM, Shim TS, Kim WS, Ryu JS, Choi CM. Efficacy comparison between (18)F-FDG PET/CT and bone scintigraphy in detecting bony metastases of non-small-cell lung cancer. Lung Cancer 2009 Sep;65(3):333-8
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


3. Cook GJ, Fogelman I. The role of positron emission tomography in the management of bone metastases. Cancer 2000 Jun 15;88(12 Suppl):2927-33
Get full text
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8. Napoli LD, Hansen HH, Muggia FM, Twigg HL. The incidence of osseous involvement in lung cancer, with special reference to the development of osteoblastic changes. Radiology 1973 Jul;108(1):17-21
Get full text
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9. Coleman RE, Mashiter G, Whitaker KB, Moss DW, Rubens RD, Fogelman I. Bone scan flare predicts successful systemic therapy for bone metastases. J Nucl Med 1988 Aug;29(8):1354-9
Get full text
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10. Vogel CL, Schoenfelder J, Shemano I, Hayes DF, Gams RA. Worsening bone scan in the evaluation of antitumor response during hormonal therapy of breast cancer. J Clin Oncol 1995 May;13(5):1123-8
Get full text
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11. Schneider JA, Divgi CR, Scott AM, Macapinlac HA, Seidman AD, Goldsmith SJ, Larson SM. Flare on bone scintigraphy following Taxol chemotherapy for metastatic breast cancer. J Nucl Med 1994 Nov;35(11):1748-52
Get full text
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12. Janicek MJ, Hayes DF, Kaplan WD. Healing flare in skeletal metastases from breast cancer. Radiology 1994 Jul;192(1):201-4
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1. Flare phenomena

2. non-small cell lung cancer

3. NSCLC

4. 18F-FDG PET/CT

5. erlotinib

6. disease progression


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