Hyperostosis - an unusual radiographic presentation of Myelodysplastic Syndrome transformed to Acute Myeloid Leukemia

Authors

  • Arie Franco
  • Kristopher Neal Lewis
  • Joshua Marion Blackmon
  • Elizabeth John Manaloor

DOI:

https://doi.org/10.3941/jrcr.v4i11.569

Keywords:

Hyperostosis, Myelodysplastic Syndrome, Acute myeloid leukemia

Abstract

Acute myeloid leukemia (AML) is also referred to non-lymphocytic leukemia in the literature.   It comprises about 15% of the childhood leukemia.  There are multiple subtypes of AML from M0-M7 with approximately 45% of the cases being M0-M2 and the remaining subtypes being rare.   The definitive diagnosis relies on bone marrow biopsy showing bone marrow infiltration with leukemic cells. We describe a rare radiographic presentation of myelodysplastic syndrome (MDS) transformed to AML in an 8 month old boy who presented with a orbital wall fracture, periosteal reaction, and mixed lytic and sclerotic lesions.

Author Biographies

Arie Franco

Department of Radiology

Kristopher Neal Lewis

Department of Radiology

Joshua Marion Blackmon

Department of Radiology

Elizabeth John Manaloor

Department of Pathology

Published

2010-11-04

Issue

Section

Pediatric Radiology