Radiographic Findings of Dysplastic Cerebellar Gangliocytoma (Lhermitte-Duclos Disease) in a Woman with Cowden Syndrome: A Case Study and Literature Review

Authors

  • Gloria JongHee Joo
  • John Doumanian

DOI:

https://doi.org/10.3941/jrcr.v14i3.3814

Keywords:

Dysplastic Cerebellar Gangliocytoma, Lhermitte-Duclos, Cerebellar Tumor, Cowden Disease, Multiple Hamartoma-Neoplasm Syndrome, MRI brain

Abstract

The following case report features a middle-aged female patient, previously diagnosed with Cowden syndrome, who presented to the hospital with symptoms of headaches and changes in vision that began with no apparent cause and persisted for almost a month. MRI of the head confirmed a diagnosis of dysplastic cerebellar gangliocytoma, also known as Lhermitte-Duclos disease. This cerebellar tumor, while extremely rare in incidence, is classified as the most common type of brain lesion in adult patients with Cowden syndrome. This report will also include a comprehensive literature review of Cowden syndrome and Lhermitte-Duclos disease, with greater emphasis on the radiologic characteristics of Lhermitte-Duclos disease.

Author Biographies

Gloria JongHee Joo

MD Student at Chicago Medical School, Class of 2021

Rosalind Franklin University of Medicine and Science

John Doumanian

Board-Certified Diagnostic Radiologist

Rush Copley Medical Center

Published

2020-03-27

Issue

Section

Neuroradiology