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Baló`s concentric sclerosis (BCS) is a rare, pathologically and radiographically distinct variant of multiple sclerosis, and it is characterized by alternating rings of demyelinated and myelinated axons. The myelinated rings correlate with the isointense areas on T2- and T1-weighted images and low signal intensity on DWI; these areas alternate with the demyelinated rings, which appear as hyperintense areas on T2-weighted images, hypointense rings on T1-weighted images, areas of enhancement on post-gadolinium contrast T1-weight images, and rings of restricted diffusion (high signal intensity) on DWI.






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Baló`s concentric sclerosis: imaging findings and pathological correlation

Free full text article: Baló`s concentric sclerosis: imaging findings and pathological correlation

Abstract
Baló`s concentric sclerosis is a primary inflammatory central nervous system demyelinating disease that is considered a rare, radiographically and pathologically distinct variant of multiple sclerosis. Baló`s concentric sclerosis is characterized by alternating rings of demyelinated and myelinated axons, and it is most frequently diagnosed postmortem by autopsy or, more recently, by magnetic resonance imaging without pathologic verification. This report is of a case of Baló`s concentric sclerosis in which the patient presented with left-sided focal sensorimotor deficits. The patient`s lesion demonstrated characteristics of Baló`s concentric sclerosis by magnetic resonance imaging, but since a neoplastic process was also suspected initially, the patient underwent a surgical biopsy. This pathology sample now provides the opportunity to correlate the tissue diagnosis of demyelination with characteristic magnetic resonance imaging findings; this comparison is infrequently found in the literature.






References



1. Karaarslan E, Altintas A, Senol U. Baló`s concentric sclerosis: clinical and radiologic features of five cases. AJNR Am J Neuroradiol 2001 Aug;22(7):1362-7
Get full text
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2. Kavanaah EC, Heran MK, Fenton DM, Lapointe JS, Nugent RA, Graeb DA. Diffusion-weighted imaging findings in Balo concentric sclerosis. Br J Radiol 2006 Jul;79(943):e28-31
Get full text
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3. Li Y, Xie P, Fan X, Tang H. Baló`s concentric sclerosis presenting with benign clinical course and multiple sclerosis-like lesions on magnetic resonance images. Neurol India 2009 Jan-Feb;57(1):66-8
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


4. Mowry, EM, Woo JH, Ances BM. Baló`s concentric sclerosis presenting as a stroke-like syndrome. Nat Clin Pract Neurol 2007 Jun;3(6):349-54
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


5. Caracciolo JT, Murtagh RD, Rojiani AM, Murtagh FR. Pathognomonic MR imaging findings in Balo concentric sclerosis. American Journal of Neuroradiology 2001 Feb;22(2):292-293
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


6. Wengert O, Siebert E. Baló`s concentric sclerosis. N Engl J Med 2011 Aug;365(8):742
Get full text
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7. Mowry, EM, Woo JH, Ances BM. Technology insight: can neuroimaging provide insights into the role of ischemia in Baló`s concentric sclerosis? Nat Clin Pract Neurol. 2007 Jun;3(6):341-8
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


8. Kim MO, Lee SA, Choi CG, Huh JR, Lee MC. Balo`s concentric sclerosis: a clinical case study of brain MRI, biopsy, and proton magnetic resonance spectroscopic findings. Journal of Neurology, Neurosurgery, and Psychiatry 1997 Jun;62(6):655-8
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


9. Bitsch A, Bruhn H, Vougioukas V. Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy. American Journal of Neuroradiology 1999 Oct;20(9):1619-1627
Get full text
Find similar topics on Read this article on PubMed :: Find similar articles on Google scholarScholar :: Search for similar topics with the Radiology specific search engine Radiology search engine


10. Ng SH, Ko SF, Cheung YC, Wong HF, Wan YL. MRI features of Balo`s concentric sclerosis. The British Journal of Radiology 1999 Apr;72 (856):400-403
Get full text
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11. Popescu BF, Lucchinetti CF. Pathology of demyelinating diseases. Annu Rev Pathol 2012 Feb;7:185-217
Get full text
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12. Given CA, Stevens BS, Lee C. The MRI appearance of tumefactive demyelinating lesions. AJR Am J Roentgenol 2004 Jan;182(1):195-9
Get full text
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13. Garg RK. Acute disseminated encephalomyelitis. Postgrad Med J 2003 Jan;79(927):11-7
Get full text
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14. Kishimoto R, Yabe I, Niino M. Baló`s concentric sclerosis-like lesion in the brainstem of a multiple sclerosis patient. J Neurol 2008 May;255(5):760-1
Get full text
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