Question:

Which of the following statements regarding the effects of cocaine is true?
1. Cocaine promotes the reuptake of norepinephrine.
2. Cocaine leads to catecholamine accumulation at postsynaptic membranes.
3. Cocaine leads to vasodilatation.
4. Cocaine results in hypotension.
5. Cocaine affects the arterial endothelium via sodium potassium transporters.





Answer:

The correct answer for the question "Which of the following statements regarding the effects of cocaine is true?" is:

2. Cocaine leads to catecholamine accumulation at postsynaptic membranes.



Explanation
1. Cocaine inhibits the reuptake of norepinephrine. [Cocaine inhibits the reuptake of norepinephrine at presynaptic terminals.]

2. [Cocaine inhibits the reuptake of norepinephrine at presynaptic terminals.]

3. Cocaine leads to vasoconstriction. [Some of the effects of the catecholamine surge are tachycardia, vasoconstriction and hypertension.]

4. Cocaine results in hypertension. [Some of the effects of the catecholamine surge are tachycardia, vasoconstriction and hypertension.]

5. Cocaine effects the arterial endothelium via calcium channels. [Another mechanism of ischemia includes cocaine`s vasoconstrictive effect on the arterial endothelium via changes in calcium channels.]



From the manuscript:
Ischemic Bowel: Uncommon Imaging Findings in a Case of Cocaine Enteropathy
Radiology Case. 2013 Feb; 7(2):38-43


This article belongs to the GI section.




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From the manuscript

Ischemic Bowel: Uncommon Imaging Findings in a Case of Cocaine Enteropathy

Free full text article: Ischemic Bowel: Uncommon Imaging Findings in a Case of Cocaine Enteropathy

Abstract
While the clinical findings of cocaine-induced enteropathy from mesenteric ischemia are fairly well understood, there is a paucity of imaging description and detail in the literature that describes these findings. Imaging characteristics of cocaine-induced mesenteric ischemia on CT examination include bowel edema, mucosal enhancement, venous engorgement, mesenteric free fluid, and dilatation of the small bowel lumen. A thorough history, physical examination, and laboratory testing are critical for the diagnosis and prompt surgical intervention may be necessary. We present a case of cocaine-induced mesenteric ischemia in a 49 year old male which resolved within 24 hours of supportive therapy.






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