Question:

What is the leading cause of death in patients with systemic sclerosis?
1. Pulmonary involvement.
2. Gastrointestinal involvement.
3. Renal involvement.
4. Cardiac involvement.
5. Musculoskeletal complications.





Answer:

The correct answer for the question "What is the leading cause of death in patients with systemic sclerosis?" is:

1. Pulmonary involvement.



Explanation
Pulmonary involvement is now the leading cause of death. The two main types of significant clinically pulmonary involvement are interstitial lung disease (16-43% of patients) and pulmonary hypertension (12-25% of patients). Many patients develop some degree of both complications. [Patients with this disorder often have vascular involvement, leading to pulmonary hypertension (PHTN) as a late consequence up to 60% of patients.]



From the manuscript:
Percutaneous embolization of an incidentally diagnosed pulmonary aneurysm in a scleroderma patient
Radiology Case. 2012 Jun; 6(6):29-34


This article belongs to the Chest section.




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From the manuscript

Percutaneous embolization of an incidentally diagnosed pulmonary aneurysm in a scleroderma patient

Free full text article: Percutaneous embolization of an incidentally diagnosed pulmonary aneurysm in a scleroderma patient

Abstract
A 59-year-old female with history of progressive scleroderma and pulmonary fibrosis was referred for biopsy of a pulmonary nodule that was discovered on computed-tomography (CT) chest surveillance, not present on prior CT-scan. Imaging was suspicious for granuloma, malignancy or aneurysm. CT-Angiography (CTA), performed immediately before the procedure, did not show enhancement of the mass, followed by placement of coaxial-needle into the mass. Suspicion of aneurysm was again raised and repeat CTA demonstrated contrast filling of the aneurysm. With the coaxial-needle in the aneurysm, embolization of the sac was performed using microfibrillar collagen, followed by confirmation of containment and thrombosis with CT.






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